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Venom As Therapeutic Treatment Of Cancer?

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Updated: Thursday, May 14,2009, 12:42:08 PM
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This seems unusual, but Dr. Son and colleagues report on the effectiveness of the toxin from snake venom (SVT) Vipera lebetina turanica in the inhibition of androgen-independent prostate cancer (AICAP) in the journal Molecular Cancer Therapeutics. tcmwell.com

This seems unusual, but Dr. Son and colleagues report on the effectiveness of the toxin from snake venom (SVT) Vipera lebetina turanica in the inhibition of androgen-independent prostate cancer (AICAP) in the journal Molecular Cancer Therapeutics. ...


Venom As Therapeutic Treatment Of Cancer 

This seems unusual, but Dr. Son and colleagues report on the effectiveness of the toxin from snake venom (SVT) Vipera lebetina turanica in the inhibition of androgen-independent prostate cancer (AICAP) in the journal Molecular Cancer Therapeutics.

The molecular emphasis of this report was the nuclear factor KB (NF-KB), an anti-apoptotic transcription factor that is constitutively activated in cell lines AICAP. The scientists showed that SVT inhibited growth AICAP cell lines PC-3 and DU145 with IC50 of 1.8ug/mL and 1.7, respectively. This exceeded the IC50 in LNCaP, cells sensitive to androgens (9.1ug/mL). With increasing concentrations of SVT, the number of cells distributed in the S phase of cell cycle decreased significantly in comparison with cells from other phases.

To check whether SVT can inactivate NF-KB and induce apoptosis of cells to undergo PC-3 cells treated with SVT for 24 hours were evaluated. The SBR interacts with NF-KB signal molecules by a protein-protein interaction with the cysteine residues in the NF-KB molecules.

Cell culture SVT reduced the constitutive activation of NF-KB. Interaction between SSVTVT and mutant gene constructs was suggestive that the cysteine residues are the targets of SVT in the molecule NF-KB. The expression of proteins regulating cell cycle was also altered in the SVT treated cells with decreased expression of G2-M phase cyclin B1 protein regulation and regulatory proteins in G1 phase cells. Increased apoptosis was confirmed by induction of caspase-3 and -9 activations by SVT.

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