In addition, the research team suggests that the malfunctioning of these fat cells that forms or strengthens the link between obesity and increased risk of developing life-threatening, chronic diseases such as cardiovascular disease and diabetes.
Guenther Boden, MD, led the study which involved Temple University biochemistry, endocrinology, surgery and services. Boden is a professor of medicine and head of the university is endocrinology department. The team analyzed the fat cells to take the legs of 12 people, half of whom were obese, while the other half was poor.
Using the same simple description of the disease as it applies to the body as a whole, when it does not work properly, it is ill-researchers at Temple University School of Medicine conclude the fat cells of patients obese are, by definition, sick of a lean person fat cells. They are simply not enough work right.
Describing differences on a cellular basis, Boden says the fat cells in the obese study participants were deficient in many ways. Adipose tissue itself was more inflamed in the obese than in samples of fat from the fat samples of lean, with a degree of stress observed in the endoplasmic reticulum (ER).
A portion of each cell, ER can produce proteins of the cell, and determines how proteins fold. Boden ¡¯ s team has identified evidence of stress in the ER of fat cells of obese people that affects the production and folding of certain proteins in a manner that leads, ultimately, resistance to insulin. Insulin resistance is an underlying thought to play a key role in the development of obesity-related medical diagnoses, and it contributes to the progression of these medical conditions as well.
Size and weight are often treated as body mass index (BMI), a measure of the National Institutes of Health (NIH) uses as a standard of health. The greatest person is the highest of his BMI. When the BMI climbs above 25, each point of increase in BMI indicates an increase of 25% for the risk of developing diabetes and a 10% increase in the risk of developing heart disease.
One way to reduce the amount of stress on the ER is to lose weight. Losing weight reduces the risk of developing insulin resistance, thus reducing the risk of developing the conditions, too.
Boden The research team studied the relationship between free fatty acids and ER stress. Full details of the comparison of the health status of fat cells in obese people and welding are available in September issue of Diabetes, a publication of the American Diabetes Association, which helped fund the study of soil as well as the Groff Foundation and NIH.
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