Skin mucous membrane is one of the main body of HIV invasion, many AIDS patients is their first symptom of skin damage, such as Kaposi's sarcoma, oral candidiasis, chronic herpes virus infection and molluscum contagiosum and so on.
1. Infectious skin and mucous membrane lesions 64% AlE) S associated with skin infections in patients, according to the occurrence of skin infection that mainly Th cells and skin Langerhans cells decreased, resulting in reduced immune function of skin cells, causing infection, and difficult to treatment, easy to relapse. In a variety of infections, to severe herpes simplex, herpes zoster, chronic acne-like folliculitis, and chronic mucocutaneous candidiasis most significant. When these abnormalities seen in individuals at high risk should be highly suspected that the patient has the possibility of HIV infection.
Herpes virus can activate HIV-infection and change in the expression of infected cells in asymptomatic individuals emerged the development of herpes zoster is the major signs of HIV infection. With the weakening of the immune response, herpes virus infection may become chronic, and difficult to cure. May be localized or disseminated infection was sexual, the patient may have sustained the mouth, genital, perianal herpes severe, recurrent, long-term unhealed, with deep ulcers, lesions detachable of infection.
General AIY) s very rare C; MV infection of the skin caused by the performance, but when there is poor prognosis. C; MV can cause thrombocytopenic purpura, occasional herpes or erythema, trunk and limbs often appear erythema multiforme. Since C; MV 'infection often accompanied by proctitis and colitis, so infection can spread to the perianal downstream, causing perianal ulcers.
Pox virus infection by sexual contact occurred within the perianal and external genitalia, performance, or hundreds of dozens of umbilical-shaped papules or soft wart lesions consisting of continuous disseminated; HPV infection can cause common warts and acute condyloma difficult to cure. Condyloma expressed as the anus and external genitalia of the vegetation.
Common skin fungal infections are ringworm, onychomycosis. If the Cryptococcus neoformans or Histoplasma infection spread, the skin and subcutaneous tissue can be expressed as cellulitis, ulcers, vasculitis, purpura, or pimples such damage.
Bacterial infections can be manifested as multiple skin abscesses or boils swollen, often caused by Staphylococcus aureus, in serious cases can cause severe bullous impetigo or impetigo occurred within the area of skin abrasions. Mycobacterium tuberculosis and Mycobacterium tuberculosis infection in birds: usually manifested multiple papules, swollen lymph nodes, or the formation of fistula.
2. Non-infectious skin and mucous membrane lesions of AIDS patients, there may be some other skin lesions. The most common is seborrheic dermatitis, herpes or measles-like itchy rash, like ring-ring granuloma processes, folliculitis, yellow nail syndrome, vasculitis, cluster-like hair, blood stains, eosinophilic pus blisters folliculitis, multi-eyelashes psychosis.
Seborrheic dermatitis-like rash in AIDS symptoms appear either before or simultaneously, the incidence rate as high as 46%, than the ordinary person a high incidence rate of about 9 times. The pathogen is unclear, mostly occurs in the scalp, eyebrows, eyes, or under the ears, may also occur in the armpits, chest, groin and other parts, the performance of the substrate in the erythema have a thick yellow oil-like scales, showed facial disc, and sometimes with fever, joint pain, and diffuse adenosis, lasting refractory should be identified and systemic lupus erythematosus. Sometimes these rashes like psoriasis. Biopsy, showing superficial perivascular lymphocyte infiltration, and plasma cells appear in the dermis, epidermal hyperplasia with mild psoriasis, the cells scattered within the necrotic parakeratotic cells.
3. Neoplastic cutaneous manifestations of KS, lymphoma, skin squamous cell carcinoma, basal cell carcinoma. Sarcoma in AIDS patients, KS is the most common initial manifestation of disseminated sarcoma was single or a color change from light brown to dark purple, its shape can be plaque to the tumor nodules, also showed follicular, herpes zoster-like or linear, and non-AIDS patients compared with more atypical KS sarcoma. In addition, AIDS patients with KS sarcoma are usually of invasion and the mucous membranes. Occurrence of AIDS patients and non-Hodgkin's lymphoma, Hodgkin's may have a skin nodules. Cutaneous squamous cell carcinoma of the rectum and anus primary tumors are more common, the former with herpes and HPV infection, which is related with anal sex.