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Male Circumcision Reduces HIV

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Updated: Tuesday, Sep 15,2009, 2:08:10 PM
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Three recent trials support the African male circumcision (MC) to reduce the risk of contracting HIV among heterosexual men. After inclusion of new data from these tests in their study, the Cochrane researchers have changed their previous ctcmwell.com

Three recent trials support the African male circumcision (MC) to reduce the risk of contracting HIV among heterosexual men. After inclusion of new data from these tests in their study, the Cochrane researchers have changed their previous c...

Three recent trials support the African male circumcision (MC) to reduce the risk of contracting HIV among heterosexual men. After inclusion of new data from these tests in their study, the Cochrane researchers have changed their previous conclusions that the evidence was insufficient to recommend TM as an intervention to prevent HIV infection among heterosexual men.



MC may contribute to protect against HIV by removing the foreskin cells that the virus is particularly drawn. Called Langerhans cells, they have receptors that allow HIV entry. Earlier non-randomized studies have evaluated the association between MC and HIV, but until now, the Cochrane researchers have been unable to make strong recommendations for surgery because of a lack of high quality evidence gained randomized clinical trial.

"Research on the effectiveness of MC for HIV prevention among heterosexual men is conclusive. No tests are needed to establish that the rate of HIV infection is reduced among heterosexual men for at least the first two years of MC, "explains lead researcher, Nandi Siegfried, Co-Director of the South African Cochrane Center in South Africa Medical Research Council. "Policy makers may consider implementing the MC as an additional measure in prevention programs for HIV."


Clinical trials included in the review took place in South Africa, Uganda and Kenya between 2002 and 2006, and included a total of 11,054 men. The results show that among heterosexual men MC significantly reduces their risk of contracting HIV by 54% over two years compared to uncircumcised men. This risk reduction is the best estimate of the effect of the mean and the researchers report that the real risk will be reduced from 38 to 66%. Other research, however, is needed to determine whether TM offers any benefit to women partners of circumcised men and gay men.



HIV 

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