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The cause of atrophic gastritis

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Updated: Monday, Jan 18,2010, 4:55:52 PM
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The cause of chronic atrophic gastritis has not yet clear, may be related to the following factors:

(1) the continuation of chronic superficial gastritis: chronic atrophic gastritis, chronic superficial gastritis can be evolved. People's Liberation Army General Hospital six hospitals report on 5 to 8 years of follow-up observation of 164 cases of superficial gastritis, which turned into 34 cases of chronic atrophic gastritis (20.7%). The cause of chronic superficial gastritis, chronic atrophic gastritis may become pathogenic and aggravating factors.

(2) Genetic factors: According to Varis survey, patients with chronic atrophic gastritis among first-generation relatives, chronic atrophic gastritis was significantly higher incidence of malignant anemia genetic factors are also evident. The incidence of the familial relationship of 20 times larger than the control group, indicating chronic atrophic gastritis may be related to genetic factors.

(3) Metal contact: Workers exposed to lead a high incidence of gastric ulcer, gastric mucosal biopsy found that the incidence of atrophic gastritis is also increased. Polmer called excretion gastritis. In addition to a lot of heavy metals such as mercury, lead outside, tellurium, copper and zinc on the gastric mucosa have a certain degree of injury.

(4) Radiation: Radiation therapy ulcer disease or other tumors, gastric mucosal damage can even shrink.

(5) iron deficiency anemia: Many facts show that iron deficiency anemia and atrophic gastritis closely, Badanoch reported 50 cases of iron deficiency anemia, normal gastric mucosa, superficial gastritis and atrophic gastritis each 14%, 46% and 40%. However, the mechanism of anemia caused by gastritis is not clear. Some scholars believe that gastritis is the original disease, gastritis, stomach acid because of the low-induced iron can not be absorbed, or because of bleeding resulting in the formation of anemia; another view, first, anemia, because iron deficiency in the body so that update rate is affected by the impact of gastric mucosal inflammation-prone .

(6) biological factors: chronic infectious diseases such as hepatitis, tuberculosis and other effects on the stomach also attracted people's attention. In patients with chronic liver disease often have signs and symptoms of chronic gastritis, gastric mucosal staining also confirmed that within the gastric mucosa in patients with hepatitis B hepatitis B virus antigen-antibody complex. Ruijin Hospital reported 91 cases of atrophic gastritis patients, 24 cases (26.4%) with chronic hepatitis. Therefore, chronic liver disease with chronic diseases, especially on the stomach are noteworthy.

(7) physical factors: the clinical results showed that the incidence of this disease and age showed a significant positive correlation. Grow older, gastric function, "resistance" is also worse, vulnerable to the impact of external adverse factors caused by injury.

(8) reflux of bile or duodenal fluid: As the pyloric sphincter dysfunction or gastrojejunostomy anastomosis, bile or duodenal fluid can reflux from the stomach, and destruction of mucosal barrier, prompting H  + and pepsin Anti-loose to cause a series of pathological changes within the mucosa, causing chronic superficial gastritis, and may develop into chronic atrophic gastritis.

(9) Immune factors: in atrophic gastritis, especially in the blood of patients with gastric body gastritis, gastric juice or plasma cells in mucosal atrophy, often can be found in parietal cell antibodies, or intrinsic factor antibodies, so that the autoimmune response is chronic atrophic the cause of gastritis. In recent years, found that a small number of antral gastritis, gastrin-secreting cells in patients with antibodies, which is cell specific autoimmune antibody, an Ig G system. Some patients with atrophic gastritis in vitro lymphocyte transformation test and leukocyte migration inhibition test are abnormal, suggesting that cellular immune response in the incidence of atrophic gastritis there are also important.

(10) Helicobacter pylori (HP) infection: in 1983 the Australian scholar Marshall and Warren in patients with chronic gastritis from antral mucus layer and epithelial cells isolated for the first time HP. Since then many scholars of chronic gastritis patients with a large number of experimental studies, 60% ~ 90% of the gastric mucosa of patients with chronic gastritis train HP, and then found that the degree of HP infection in gastric mucosa a positive correlation between the degree of inflammation. 1986 World Society of Gastroenterology will be presented at the eighth session of HP infection is an important cause of chronic gastritis.

In addition, such as poor diet, long-term addicted to tobacco and alcohol, drug abuse, chronic inflammation of the upper respiratory tract, central nervous system dysfunction, damage to gastric mucosa, as well as subtotal gastrectomy, removal of secretion of gastrin in antral area, resulting in stomach mucosal barrier such as nutrition, are easy to cause damage to gastric mucosal atrophy, inflammatory changes.


Tags: gastritis atrophic

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